The objective of my work is to understand how obesity reshapes properties of intrahypothalamic neurocircuits and contributes to the development of hypertension. 

Awards

• NIH/NHLBI Ruth L. Kirschstein National Research Service Award (NRSA), 2023-2026
• Central Nervous System Section Van Harreveld Memorial Award from American Physiological Society, Experimental Biology, 2022
• Fellowship appointment on the Pharmacological Sciences Training Program (NIH T32 GM067795), University of Iowa, 2020-2022
• Horwitz and Horowitz Outstanding Undergraduate Abstract Award from American Physiological Society, Experimental Biology, 2018
• Horwitz and Horowitz Excellence in Undergraduate Research Award from American Physiological Society, Experimental Biology, 2018

Publications

1. Root KM, Akhaphong B, Molin AM, Huchthausen ME, Laule CF, Regal RR, Alejandro EU, and Regal JF: Critical Role for Macrophages in the Developmental Programming of Pancreatic β-cell Area in Offspring of Gestational Hypertension. Submitted to Diabetes, May 2022.Regal JF, Laule CF, Root KM, Gilbert JS, and Fleming SD: Reply to “Letter to the Editor: Importance of B Cells in Response to Placental Ischemia.” Am J Physiol Heart Circ Physiol 318:H726-H728, 2020. PMID: 32141767
2. Regal JF, Laule CF, Root KM, Gilbert JS, and Fleming SD: Reply to “Letter to the Editor: Importance of B Cells in Response to Placental Ischemia.” Am J Physiol Heart Circ Physiol 318:H726-H728, 2020. PMID: 32141767
3. Laule CF, Odean EJ, Wing CR, Root KM, Towner KJ, Hamm CM, Gilbert JS, Fleming SD, and Regal JF: Role of B1 and B2 Lymphocytes in Placental Ischemia-induced Hypertension. Am J Physiol Heart Circ Physiol 317.4:H732-742, 2019. PMID: 31397167
4. Regal JF, Laule CF, McCutcheon L, Root KM, Lund H, Hashmat S, and Mattson DL: The Complement System in Hypertension and Renal Damage in the Dahl SS Rat. Physiological Reports 6.6: 13655, 2018. PMID: 29595916
5. Laule CF, Wing CR, Odean EJ, Wilcox JA, Gilbert JS, and Regal JF: Effect of Nicotine on Placental Ischemia-induced Complement Activation and Hypertension in the Rat. J Immunotoxicol 14.1:235-240, 2017. PMID: 29185370

Abstracts

1. Laule CF, Guo DF, and Rahmouni K: Brainstem BBSome Regulates Glucose Metabolism and High Fat Diet Sensitivity. FASEB J 36:3611, 2022. Abstract also presented at FOEDRC Diabetes Research Day 2022.
2. Root KM, Akhaphong B, Molin AM, Huchthausen ME, Laule CF, Regal RR, Alejandro EU, and Regal JF: Role of Macrophages in Developmental Programming of Pancreatic β-cell Area in Offspring of Gestational Hypertension. FASEB J 36:2645, 2022.
3. Laule CF, Odean EJ, Wing CR, Gilbert JS, Fleming SD and Regal JF: Depletion of B1 and B2 lymphocytes in placental ischemia-induced hypertension in the rat. FASEB J 32:729.4, 2019.